Invitrogen

IRF4 Polyclonal Antibody

查看其他36个IRF4抗体

抗体检测数据 (3)

IRF4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IRF4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IRF4 Antibody (PA5-79517) in IHC (P)

Immunohistochemistry analysis of MUM1 on paraffin-embedded human tonsil tissue. Sample was incubated with MUM1 polyclonal antibody (Product# PA5-79517).

IRF4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IRF4 Antibody in Western Blot (WB)

IRF4 Antibody in Western Blot (WB)

Product Image Gallery

IRF4 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of MUM1 on paraffin-embedded human tonsil tissue. Sample was incubated with MUM1 polyclonal antibody (Product# PA5-79517).

IRF4 Antibody in Western Blot (WB) — Western blot analysis of MUM1 in Lane 1: HeLa whole cell lysate, Lane 2: JURKAT whole cell lysate using 40-50 µg per well. Sample was incubated with MUM1 (Product # PA5-79517) at a dilution of 0.5 µg/mL.

IRF4 Antibody in Western Blot (WB) — Western blot analysis of MUM1 in recombinant human MUM1 protein using 0.5 ng per well. Sample was incubated with MUM1 polyclonal antibody (Product # PA5-79517) at a dilution of 0.5 µg/mL.

产品信息

PA5-79517

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL

-

免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

E.coli-derived human MUM1 recombinant protein (Position: E272-E451).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5mg BSA

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2746633

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

靶标信息

The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. IRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Interferon regulatory factor 4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1; NF-EM5

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基因别名: IRF4; LSIRF; MUM1; NF-EM5; SHEP8

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UniProt ID: (Human) Q15306

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Entrez Gene ID: (Human) 3662

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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein-lysine N-methyltransferase activity sequence-specific DNA binding winged helix/forkhead transcription factor

参与通路

transcription from RNA polymerase II promoter peptidyl-lysine methylation negative regulation of toll-like receptor signaling pathway T cell activation defense response to protozoan myeloid dendritic cell differentiation positive regulation of DNA binding histone H3 acetylation histone H4 acetylation positive regulation of interleukin-10 biosynthetic process positive regulation of interleukin-2 biosynthetic process positive regulation of interleukin-13 biosynthetic process positive regulation of interleukin-4 biosynthetic process regulation of T-helper cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter interferon-gamma-mediated signaling pathway type I interferon signaling pathway T-helper 17 cell lineage commitment