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产品信息
PA5-32882
产品规格
种属反应
Bat,
Dog,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 18 amino acid peptide from C-terminus of human ITGA4 / Integrin Alpha 4.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550343
产品详细信息
In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Dog, Bat, Hamster, Panda, Rabbit, Pig (100%).
靶标信息
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; integrin alpha 4; Integrin alpha-4; Integrin alpha-IV; integrin alpha4B; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); ITGA-IV; LPAM subunit alpha; Lymphocyte Peyer patch adhesion molecules subunit alpha; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha
基因别名: CD49D; I79_008633; IA4; ITGA4; Itga4B
UniProt ID: (Human) P13612, (Mouse) Q00651
Entrez Gene ID: (Rabbit) 100346103, (Pig) 100521477, (Dog) 488429, (Human) 3676, (Chinese hamster) 100762323, (Rat) 311144, (Mouse) 16401
cell-matrix adhesion involved in ameboidal cell migration
leukocyte cell-cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
B cell differentiation
extracellular matrix organization
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
endodermal cell differentiation
receptor clustering
regulation of immune response
leukocyte migration
leukocyte tethering or rolling
diapedesis
cellular response to cytokine stimulus
negative regulation of protein homodimerization activity
import into cell
positive regulation of leukocyte tethering or rolling
clathrin-mediated extracellular exosome endocytosis
positive regulation of T cell migration
blood vessel remodeling
positive regulation of leukocyte migration
cell adhesion
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
heart development
cell migration
face development
chorio-allantoic fusion
T cell migration
positive regulation of leukocyte cell-cell adhesion
single organismal cell-cell adhesion
mesenchyme development
visceral serous pericardium development
