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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: inosine triphosphatase (nucleoside triphosphate pyrophosphatase); inosine triphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; Inosine triphosphate pyrophosphatase; inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; inosine triphosphate pyrophosphohydrolase; ITPase; ITPase {ECO:0000255|HAMAP-Rule:MF_03148}; My049 protein; Non-canonical purine NTP pyrophosphatase; non-canonical purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; Non-standard purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; NTPase; NTPase {ECO:0000255|HAMAP-Rule:MF_03148}; nucleoside triphosphate pyrophosphatase; Nucleoside-triphosphate diphosphatase; nucleoside-triphosphate diphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; Nucleoside-triphosphate pyrophosphatase; nucleoside-triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; Putative oncogene protein hlc14-06-p
基因别名: 2010016I08Rik; AU020102; C20orf37; dJ794I6.3; HLC14-06-P; Itp; ITPA; ITPase; My049; NTPase; OK/SW-cl.9
UniProt ID: (Human) Q9BY32, (Rat) D3ZW55, (Mouse) Q9D892
Entrez Gene ID: (Human) 3704, (Rat) 311422, (Mouse) 16434