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产品信息
ITPR2-201AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 100-150 on rat Inosital 1,4,5-triphosphate receptor type 2 protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neuro-transmitters. Upon binding to IP3R, IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240 kDa glycoprotein subunits. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations. Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. IP3R type I (IP3R-I) has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II is found predominantly in the brain. IP3R-III is known to be expressed in pancreatic islets, kidney, and the gastrointestinal tract.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cilia and flagella associated protein 48; inositol 1,4,5-triphosphate receptor 2; inositol 1,4,5-triphosphate receptor 5; inositol 1,4,5-triphosphate receptor, type 2; Inositol 1,4,5-trisphosphate receptor type 2; Inositol 1,4,5-trisphosphate type V receptor; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2; inositol triphosphate receptor type 2; inositol trisphosphate receptor type 2; insP3R2; IP3 receptor; IP3 receptor isoform 2; IP3R 2; Type 2 inositol 1,4,5-trisphosphate receptor; Type 2 InsP3 receptor
基因别名: AI649341; ANHD; CFAP48; InsP3R-2; InsP3R-5; INSP3R2; IP3R2; ITPR2; Itpr5
UniProt ID: (Human) Q14571, (Mouse) Q9Z329, (Rat) P29995
Entrez Gene ID: (Human) 3709, (Mouse) 16439, (Rat) 81678
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium ion transmembrane transporter activity
phosphatidylinositol binding
ion channel activity
calcium channel activity
calcium ion binding
calcium-release channel activity
inositol 1,4,5 trisphosphate binding
ligand-gated ion channel
response to hypoxia
transport
signal transduction
platelet activation
inositol phosphate-mediated signaling
regulation of insulin secretion
release of sequestered calcium ion into cytosol
cellular response to cAMP
cellular response to ethanol
regulation of cardiac conduction
ion transport
calcium ion transport
transmembrane transport
calcium ion transmembrane transport
cellular response to hypoxia
