Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-79544
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of human ITPR3 (70-95aa QYWKAKQTKQDKEKIADVVLLQKLQH).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2746659
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: inositol 1,4,5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor, type 3; Inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor, type 3; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; insP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R 3; IP3R-3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
基因别名: IP3R; IP3R3; IP3R3X; Itpr-3; ITPR3
UniProt ID: (Human) Q14573, (Mouse) P70227, (Rat) Q63269
Entrez Gene ID: (Human) 3710, (Mouse) 16440, (Rat) 25679
inositol hexakisphosphate binding
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium ion binding
protein binding
calcium-release channel activity
phosphatidylinositol binding
inositol 1,3,4,5 tetrakisphosphate binding
inositol 1,4,5 trisphosphate binding
ion channel activity
calcium channel activity
calcium ion transmembrane transporter activity
ligand-gated ion channel
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
memory
platelet activation
inositol phosphate-mediated signaling
regulation of insulin secretion
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
release of sequestered calcium ion into cytosol
protein homooligomerization
protein heterooligomerization
response to calcium ion
long-term synaptic potentiation
calcium ion transport into cytosol
cellular response to cAMP
regulation of cardiac conduction
transport
ion transport
calcium ion transport
transmembrane transport
calcium ion transmembrane transport
