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Immunogen sequence: VRDNICGALA RLLMASPTRK PEPQVLAALL HALPLKEDLE EWVTIGRLFS FLYQSSPDQV IDVAPELLRI CSLILADNKI PPD
Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Imp4; Imp4b; Importin-4; Importin-4b; Ran-binding protein 4; RanBP4
基因别名: Imp4; IMP4B; IPO4; RANBP4
UniProt ID: (Human) Q8TEX9
Entrez Gene ID: (Human) 79711
分子生物学功能:
transporter