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Invitrogen
JLP Polyclonal Antibody
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FIGURE: 1 / 2
JLP Antibody (PA5-100730) in ICC/IF
Immunocytochemistry analysis of JLP in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with JLP polyclonal antibody (Product # PA5-100730) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-100730
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SPAG9(Accession O60271), corresponding to amino acid residues L1266-V1316.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total JIP4.
Target Information
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain, and a cytoplasmic region. This protein acts as a receptor for glycoprotein D of herpes simplex viruses 1 and 2, and pseudorabies virus and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome as well as non-syndromic cleft lip with or without cleft palate. Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-Jun NH2-terminal kinase-associated leucine zipper protein; C-Jun-amino-terminal kinase-interacting protein 4; Cancer/testis antigen 89; CT89; HLC-6; Human lung cancer oncogene 6 protein; JIP-4; JLP; JNK interacting protein; JNK-associated leucine-zipper protein; JNK-interacting leucine zipper; JNK-interacting protein 4; JNK/SAPK-associated protein; JNK/SAPK-associated protein 2; JSAP2; lung cancer oncogene 4; Max-binding protein; Mitogen-activated protein kinase 8-interacting protein 4; PHET; proliferation-inducing gene 6; Proliferation-inducing protein 6; Protein highly expressed in testis; sperm associated antigen 9 variant 5; Sperm surface protein; Sperm-associated antigen 9; Sperm-specific protein; Sunday driver 1
Gene Aliases: 3110018C07Rik; 4733401I23Rik; 4831406C20Rik; AW552012; CT89; HLC-6; HLC4; HLC6; HSS; JIP-4; JIP4; JLP; JSAP2; JSAP2a; KIAA0516; MAPK8IP4; PHET; PIG6; SPAG9; SYD1
UniProt ID: (Human) O60271, (Mouse) Q58A65
Entrez Gene ID: (Human) 9043, (Mouse) 70834
activation of JUN kinase activity
spermatogenesis
positive regulation of cell migration
retrograde transport, endosome to Golgi
positive regulation of neuron differentiation
striated muscle cell differentiation
positive regulation of muscle cell differentiation
protein homooligomerization
negative regulation of protein homodimerization activity
activation of MAPK activity
positive regulation of signal transduction
vesicle-mediated transport
positive regulation of MAPK cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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