Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
MA5-15092
产品规格
种属反应
Mouse,
Rat,
Human
宿主/亚型
Rabbit
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
K.238.3
抗原
Synthetic peptide corresponding to human JNK3
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
<0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_10977683
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). MAPK10 is involved in neuronal apoptosis and phosphorylates MAP2K4. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (NhpK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: c-Jun N-terminal kinase 3; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; mitogen activated protein kinase 10; Mitogen-activated protein kinase 10; OTTHUMP00000161181; OTTHUMP00000161183; OTTHUMP00000218718; p54-beta; SAPK-beta; SAPK/Erk/kinase 2; SAPK1b; Stress activated protein kinase beta; Stress-activated protein kinase 1b; Stress-activated protein kinase JNK3
基因别名: C230008H04Rik; JNK3; JNK3A; JNK3B1; JNK3B2; MAPK10; p493F12; p54bSAPK; PRKM10; SAPb; SAPK(beta); SAPK1B; SAPKC; Serk2
UniProt ID: (Human) P53779, (Mouse) Q61831, (Rat) P49187
Entrez Gene ID: (Human) 5602, (Mouse) 26414, (Rat) 25272
JUN kinase activity
MAP kinase kinase activity
protein binding
ATP binding
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
activation of MAPK activity
protein phosphorylation
signal transduction
JNK cascade
JUN phosphorylation
response to light stimulus
Fc-epsilon receptor signaling pathway
regulation of circadian rhythm
rhythmic process
regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription from RNA polymerase II promoter
phosphorylation
locomotor rhythm
MAPK cascade
