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Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
A BLAST analysis was used to suggest cross reactivity with Jagged-1 protein from human, chimpanzee, rat and mouse based on 100% homology with the immunizing sequence. Partial reactivity is expected against dog (81%) and Xenopus laevis (85%) based on partial sequence homologies as indicated. Reactivity against homologues from other sources is not known.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD339; jagged canonical Notch ligand 1; Jagged1; Protein jagged-1; Serrate-1
基因别名: ABE2; AGS; AHD; AWS; CD339; Gsfabe2; HJ1; Htu; JAG1; JAGL1; Ozz; Ser-1
UniProt ID: (Human) P78504, (Mouse) Q9QXX0
Entrez Gene ID: (Human) 182, (Mouse) 16449