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产品信息
PA5-53357
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642868
产品详细信息
Immunogen sequence: SQHIPTAEGA SGSNTEEEIR MELSPDLISA CLALEKYLDN PNALTERELK VAYTTVLQEW LRLACRSDAH PELVRRHLVT FRAMSARLLD YVVNIADSNG NTALHYSVSH ANFPVVQ
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 90%.
靶标信息
This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair.
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生物信息学
蛋白别名: Ankyrin repeat domain-containing protein 25; kidney ankyrin repeat-containing protein 2; KN motif and ankyrin repeat domain-containing protein 2; Matrix-remodeling-associated protein 3; SIP; SRC-1-interacting protein; SRC-interacting protein; SRC1-interacting protein
基因别名: ANKRD25; KANK2; KIAA1518; MXRA3; PPKWH; SIP
UniProt ID: (Human) Q63ZY3
Entrez Gene ID: (Human) 25959
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
apoptotic process
negative regulation of cell proliferation
negative regulation of intracellular estrogen receptor signaling pathway
negative regulation of programmed cell death
negative regulation of vitamin D receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
