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Immunogen sequence: NLIEAETEGQP LQLFSPSNPP EIVISSREDN HAHQTLLHHP NATHNHQHAG TTASSTTFPK ANKRK
Highest antigen sequence identity to the following orthologs - mouse 95%, rat 95%.
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: KCa2.3; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; SK3; SKCa 3; small conductance calcium-activated potassium channel 3; Small conductance calcium-activated potassium channel protein 3
基因别名: hSK3; K3; KCa2.3; KCNN3; SK3; SKCA3
UniProt ID: (Human) Q9UGI6
Entrez Gene ID: (Human) 3782