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KIDINS220 Antibody (PA5-116475) in ICC/IF
Immunocytochemical analysis of KIDINS220 in PC-12 cells using a KIDINS220 polyclonal antibody (Product #PA5-116475). Formalin fixed cells, as seen in green, were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA for 15 minutes at room temperature. Cells were probed with the primary antibody ( 1:200) for 1 hour at room temperature, washed with PBS.... View More
产品信息
PA5-116475
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within Human Kidins220 aa 1,325-1,374
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2901107
产品详细信息
Positive controls: SH-SY5Y cell lysates, N2A, PC-12, human pancreas tissue, human breast cancer tissue, mouse brain tissue, SH-SY5Y.
靶标信息
This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ankyrin repeat-rich membrane spanning; ankyrin repeat-rich membrane spanning protein; Ankyrin repeat-rich membrane-spanning protein; kinase D-interacting substance 220; kinase D-interacting substance of 220 kDa; Kinase D-interacting substrate of 220 kDa; kinase D-interacting substrate, 220kDa; MGC163482; truncated KIDINS220
基因别名: 3110039L19Rik; AI194387; AI316525; ARMS; C330002I19Rik; KIAA1250; KIDINS220; mKIAA1250
UniProt ID: (Human) Q9ULH0, (Rat) Q9EQG6
Entrez Gene ID: (Human) 57498, (Rat) 116478, (Mouse) 77480
