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KIR2DL4 Antibody (MA1-10111) in Flow
Signal transduction and targeted therapy 2021 -
Fig. 2 HLA-G engages KIR2DL4 on NK cells to suppress trastuzumab-elicited ADCC. a FCM assay of the expression of the indicated receptors on human PBMC-derived primary NK cells. b NK cells in the presence of trastuzumab were cocultured with HER2-overexpressing breast cancer cells at the indicated E:T ratios supplemented with or without the indicated blocking antibodies. The toxicity of NK cells to malignant ... View More
产品信息
MA1-10111
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
mAb#33
抗原
NK3.3 cells and KIR2DL4-Ig fusion protein
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11155224
产品详细信息
This antibody recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals.
靶标信息
CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-gamma secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
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生物信息学
蛋白别名: CD158 antigen-like family member D; CD158d; G9P; Killer cell immunoglobulin-like receptor 2DL4; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4; Killer cell inhibitory receptor 103AS; killer Ig receptor; killer-cell immunoglobulin-like receptor; killer-cell immunoglobulin-like receptor 2DL4; KIR-103AS; MHC class I NK cell receptor KIR103AS; natural killer cell inhibitory receptor; natural killer cell receptor; NK cell receptor
基因别名: CD158D; G9P; KIR; KIR-103AS; KIR-2DL4; KIR103; KIR103AS; KIR2DL4
UniProt ID: (Human) Q99706
Entrez Gene ID: (Human) 3805
