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KIR3DL2 Antibody (PA5-87645) in WB
Western blot analysis of KIR3DL2 in extracts of various cell lines. Samples were incubated with KIR3DL2 Polyclonal antibody (Product # PA5-87645) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-87645
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 361-455 of human KIR3DL2 (NP_0067282)
偶联物
形式
Liquid
浓度
1.65 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804315
产品详细信息
Positive Samples: HL-60, LO2, MCF7, Mouse spleen, Mouse liver, Rat spleen; Cellular Location: Cell membrane, Single-pass type I membrane protein
Immunogen sequence: YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ LDHCVFIQRK ISRPSQRPKT PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG LEGVF
靶标信息
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD158 antigen-like family member K; CD158k; Killer cell immunoglobulin-like receptor 3DL2; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2; killer Ig receptor; killer immunoglobulin-like receptor-like 2; killer-cell immunoglobulin-like receptor; killer-cell immunoglobulin-like receptor 3DL2; KIR antigen 3DL2; KIR-like receptor 2; LOC727787; MHC class I NK cell receptor; natural killer cell receptor; Natural killer-associated transcript 4; NKAT-4; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clone CL-5; p70 NK receptor CL-5
基因别名: 3DL2; CD158K; KIR-3DL2; KIR3DL2; Kirl2; NKAT-4; NKAT4; NKAT4B; p140
UniProt ID: (Human) P43630
Entrez Gene ID: (Human) 3812, (Mouse) 245615
