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产品信息
PA5-50513
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues near the C terminal of human KiSS-1 metastasis-suppressor
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2635966
产品详细信息
The antibody detects endogenous levels of total KISS1 protein.
靶标信息
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 0610012C01Rik; Kiss1 metastasis-suppressor; Kisspeptin-1; malignant melanoma metastasis-suppressor; Metastasis-suppressor KiSS-1; metastin; prepro-kisspeptin
基因别名: HH13; KiSS-1; KISS1; kisspeptin; metastatin; PP5098
UniProt ID: (Human) Q15726, (Mouse) Q6Y4S4
Entrez Gene ID: (Human) 3814, (Mouse) 280287
cytoskeleton organization
negative regulation of cell proliferation
positive regulation of luteinizing hormone secretion
positive regulation of MAPK cascade
positive regulation of synaptic transmission
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
generation of ovulation cycle rhythm
positive regulation of growth hormone secretion
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
negative regulation of cell migration
