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KLRB1 Antibody (PA5-93293) in WB
Western blot analysis of KLRB1 in extracts of various cell lines. Samples were incubated with KLRB1 Polyclonal antibody (Product # PA5-93293) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-93293
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 73-140 of human KLRB1 (NP_0022491)
偶联物
形式
Liquid
浓度
0.83 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806707
产品详细信息
Immunogen sequence: KCSVDIQQSR NKTTERPGLL NCPIYWQQLR EKCLLFSHTV NPWNNSLADC STKESSLLLI RDKDELIH; Positive Samples: Rat liver, HT-29, Mouse liver; Cellular Location: Membrane, Single-pass type II membrane protein
靶标信息
KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD-161) protein is classified as a type II membrane protein because it has an external C terminus. KLRB1 cell surface antigen is expressed by almost all NK cells and in a small subset of CD3+ve T cells. KLRB1 is a homodimeric cell surface protein, comprising two chains with molecular weights ranging from 40-44kDa. KLRB1 plays an inhibitory role on natural killer (NK) cells. Activation of KLRB1 leads to acid sphingomyelnase/SMPD1 stimulation and an increase in intracellular ceramide. Moreover, there is also an activation of AKT1/PKB and RPS6KA1/RSK1 kinase stimulation, and T cell proliferation by anti-CD3. KLRB1 acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope and to the N-acetyllactosamine epitope. KLRB1 also binds to CLEC2D/LLT1 as a ligand, and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Antigen 3.2.3; C-type lectin domain family 5 member B; CD161; CD161 antigen-like family member A; CD161 antigen-like family member B; CD161a; CD161b; HNKR-P1a; Immunoreceptor NKR-P1E; immunoreceptor NKR-P1G; Inhibitory receptor NKR-P1B; killer cell lectin-like receptor subfamily A member 1 complex; Killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B member 1 complex; Killer cell lectin-like receptor subfamily B member 1A; killer cell lectin-like receptor subfamily B member 1B; Killer cell lectin-like receptor subfamily B member 1B allele A; Killer cell lectin-like receptor subfamily B member 1B allele B; killer cell lectin-like receptor subfamily B member 1B allele C; killer cell lectin-like receptor subfamily B member 1D; killer cell lectin-like receptor subfamily B member 1F; Killer cell lectin-like receptor subfamily B member 1G; killer cell lectin-like receptor subfamily B, member 1; klrb1b {ECO:0000312|EMBL:AAQ11375.1}; klrb1b {ECO:0000312|RGD:2975}; lectin-like transmembrane protein Nkrp1g; Ly-55A; ly-55b; Ly-55d; lymphocyte antigen 55; lymphocyte antigen 55 complex, locus A; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus D; Lymphocyte antigen 55A; lymphocyte antigen 55b; Lymphocyte antigen 55d; MGC138614; natural killer cell receptor; natural killer cell receptor protein NKR-P1A; natural killer cell receptor protein NKR-P1B; natural killer cell receptor-P1; Natural killer cell surface protein NKR-P1B allele B6; Natural killer cell surface protein NKR-P1B allele RNK/SD/BN/F344; natural killer cell surface protein NKR-P1B allele SJL/BALB; natural killer cell surface protein NKR-P1B allele TO; Natural killer cell surface protein NKR-P1G; Natural killer cell surface protein P1-2; Natural killer cell surface protein P1-3.2.3; Natural killer cell surface protein P1A; Natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e; NKR-P1 2; NKR-P1 3.2.3; NKR-P1 34; NKR-P1.7; NKR-P1A; NKR-P1D
基因别名: 4930431A04Rik; CD161; CLEC5B; Gm4696; hNKR-P1A; KLRB1; Klrb1a; Klrb1b; Klrb1d; Klrb1f; Klrb1g; Klrb6; Ly-55; ly-55A; Ly55; Ly55a; Ly55b; Ly55d; NKR; NKR-P1; NKR-P1.7; NKR-P1A; NKR-P1B; NKR-P1D; Nkr-p1e; NKR-P1G; Nkrp-1e; Nkrp1-a; Nkrp1-b; NKRP12; NKRP1A; Nkrp1b; Nkrp1d; Nkrp1e; Nkrp1g
UniProt ID: (Human) Q12918, (Rat) Q0ZUP0, (Mouse) Q0ZUP1, (Rat) P27471, (Mouse) P27811, (Rat) A4KWA1, (Mouse) Q99JB4
Entrez Gene ID: (Human) 3820, (Rat) 689817, (Mouse) 100043861, (Rat) 362443, (Mouse) 17057, (Rat) 25192, (Mouse) 80782
