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产品信息
MA5-30977
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
008
抗原
Recombinant Mouse Klrb1a protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2786642
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse Klrb1a.
靶标信息
KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD-161) protein is classified as a type II membrane protein because it has an external C terminus. KLRB1 cell surface antigen is expressed by almost all NK cells and in a small subset of CD3+ve T cells. KLRB1 is a homodimeric cell surface protein, comprising two chains with molecular weights ranging from 40-44kDa. KLRB1 plays an inhibitory role on natural killer (NK) cells. Activation of KLRB1 leads to acid sphingomyelnase/SMPD1 stimulation and an increase in intracellular ceramide. Moreover, there is also an activation of AKT1/PKB and RPS6KA1/RSK1 kinase stimulation, and T cell proliferation by anti-CD3. KLRB1 acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope and to the N-acetyllactosamine epitope. KLRB1 also binds to CLEC2D/LLT1 as a ligand, and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD161 antigen-like family member A; CD161 antigen-like family member B; CD161a; CD161b; immunoreceptor NKR-P1G; Inhibitory receptor NKR-P1B; killer cell lectin-like receptor subfamily A member 1 complex; Killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B member 1 complex; Killer cell lectin-like receptor subfamily B member 1A; killer cell lectin-like receptor subfamily B member 1B allele A; Killer cell lectin-like receptor subfamily B member 1B allele B; killer cell lectin-like receptor subfamily B member 1D; Killer cell lectin-like receptor subfamily B member 1G; lectin-like transmembrane protein Nkrp1g; Ly-55A; ly-55b; Ly-55d; lymphocyte antigen 55; lymphocyte antigen 55 complex, locus A; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus D; Lymphocyte antigen 55A; lymphocyte antigen 55b; Lymphocyte antigen 55d; MGC138614; natural killer cell receptor; natural killer cell receptor protein NKR-P1A; natural killer cell receptor protein NKR-P1B; natural killer cell receptor-P1; Natural killer cell surface protein NKR-P1B allele B6; natural killer cell surface protein NKR-P1B allele SJL/BALB; Natural killer cell surface protein NKR-P1G; Natural killer cell surface protein P1-2; Natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e; NKR-P1 2; NKR-P1 34; NKR-P1.7; NKR-P1A; NKR-P1D
基因别名: 4930431A04Rik; Gm4696; Klrb1; Klrb1a; Klrb1b; Klrb1d; Klrb1g; Klrb6; Ly-55; ly-55A; Ly55; Ly55a; Ly55b; Ly55d; NKR-P1.7; NKR-P1A; NKR-P1B; NKR-P1D; NKR-P1G; Nkrp-1e; Nkrp1-a; Nkrp1-b; NKRP12; Nkrp1a; Nkrp1b; Nkrp1d; Nkrp1g
UniProt ID: (Mouse) Q0ZUP1, (Mouse) P27811, (Mouse) Q99JB4
Entrez Gene ID: (Mouse) 100043861, (Mouse) 17057, (Mouse) 80782
