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产品信息
MA5-17535
产品规格
种属反应
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
10-78
抗原
60 kDa disulfide linked homodimer NKR-P1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2538925
靶标信息
KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD-161) protein is classified as a type II membrane protein because it has an external C terminus. KLRB1 cell surface antigen is expressed by almost all NK cells and in a small subset of CD3+ve T cells. KLRB1 is a homodimeric cell surface protein, comprising two chains with molecular weights ranging from 40-44kDa. KLRB1 plays an inhibitory role on natural killer (NK) cells. Activation of KLRB1 leads to acid sphingomyelnase/SMPD1 stimulation and an increase in intracellular ceramide. Moreover, there is also an activation of AKT1/PKB and RPS6KA1/RSK1 kinase stimulation, and T cell proliferation by anti-CD3. KLRB1 acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope and to the N-acetyllactosamine epitope. KLRB1 also binds to CLEC2D/LLT1 as a ligand, and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain.
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生物信息学
蛋白别名: Antigen 3.2.3; CD161 antigen-like family member A; CD161 antigen-like family member B; CD161a; CD161b; Immunoreceptor NKR-P1E; Killer cell lectin-like receptor subfamily B member 1; Killer cell lectin-like receptor subfamily B member 1A; killer cell lectin-like receptor subfamily B member 1B; Killer cell lectin-like receptor subfamily B member 1B allele A; killer cell lectin-like receptor subfamily B member 1B allele C; killer cell lectin-like receptor subfamily B member 1F; Killer cell lectin-like receptor subfamily B member 1G; klrb1b {ECO:0000312|EMBL:AAQ11375.1}; klrb1b {ECO:0000312|RGD:2975}; MGC138614; natural killer cell receptor; Natural killer cell surface protein NKR-P1B allele RNK/SD/BN/F344; natural killer cell surface protein NKR-P1B allele TO; Natural killer cell surface protein NKR-P1G; Natural killer cell surface protein P1-3.2.3; Natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e; NKR-P1 3.2.3; NKR-P1A
基因别名: Klrb1; Klrb1a; Klrb1b; Klrb1d; Klrb1f; Klrb1g; Klrb6; NKR-P1A; Nkr-p1b; Nkr-p1e; NKR-P1G; Nkrp-1e; Nkrp1a; Nkrp1b; Nkrp1e; Nkrp1g
UniProt ID: (Rat) Q0ZUP0, (Rat) P27471, (Rat) A4KWA1
Entrez Gene ID: (Rat) 689817, (Rat) 362443, (Rat) 25192
