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KOP kappa-Opioid Receptor Antibody (7TM0318N) in WB
Analysis of dose-dependent kappa-Opioid Receptor phosphorylation using two phosphosite-specific antibodies. Upper two panels, HEK293 cells stably expressing the kappa-Opioid Receptor (KOP) were either not exposed or exposed to increasing concentrations of selective kappa-opioid receptor Agonist U50, 488H ranging from 0. 1 nM to 1 µM for 30 minutes. Cells were lysed and immunoblotted with the anti-pS356/pT35... View More
产品信息
7TM0318N
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide presents carboxyl - terminal tail of human KOP.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice (domestic); Dry ice (international)
靶标信息
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: K-OR-1; kappa opioid receptor; Kappa-type opioid receptor; KOPR1; KOR-1; MSL-1; Opiate receptor, kappa-1; opioid receptor, kappa 1; opioid receptor, kappa 2; Ork1
基因别名: K-OR-1; KOR; KOR-1; MSL-1; OPRK; OPRK1; Oprk2; R21; Ror-d
UniProt ID: (Human) P41145, (Mouse) P33534, (Rat) P34975
Entrez Gene ID: (Human) 4986, (Mouse) 18387, (Rat) 29335
immune response
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
sensory perception
behavior
locomotory behavior
response to radiation
sensory perception of pain
adenylate cyclase-inhibiting opioid receptor signaling pathway
response to insulin
positive regulation of dopamine secretion
negative regulation of luteinizing hormone secretion
opioid receptor signaling pathway
positive regulation of locomotion
maternal behavior
eating behavior
response to morphine
response to estrogen
estrous cycle
response to ethanol
regulation of saliva secretion
behavioral response to cocaine
sensory perception of temperature stimulus
defense response to virus
regulation of sensory perception of pain
cellular response to lipopolysaccharide
positive regulation of p38MAPK cascade
positive regulation of potassium ion transmembrane transport
regulation of aerobic respiration
response to acrylamide
conditioned place preference
regulation of energy homeostasis
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
