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Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: PAPPLPPSAT PPSPLHPSPQ CTRQQKNFNL PASHYYKYKQ QFIFPDVVPV PETPTRAPQV ILHPVTSNPI LEGNPLLQIE VEPTSENEEV
KSR2 serine/threonine kinase or kinase suppressor of Ras 2 specifically regulates the activity of MEKK3 and COT but not other members of the MAP3K family. KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans. Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: hKSR2; Kinase suppressor of Ras 2
基因别名: KSR2
UniProt ID: (Human) Q6VAB6
Entrez Gene ID: (Human) 283455