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Kir2.1 (KCNJ2) Antibody (PA5-88883) in WB
Western blot analysis of Kir2.1 (KCNJ2) in extracts of various cell lines. Samples were incubated with Kir2.1 (KCNJ2) Polyclonal antibody (Product # PA5-88883) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-88883
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 318-427 of human KCNJ2 (NP_0008821)
偶联物
形式
Liquid
浓度
1.72 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805194
产品详细信息
Immunogen sequence: NEILWGHRYE PVLFEEKHYY KVDYSRFHKT YEVPNTPLCS ARDLAEKKYI LSNANSFCYE NEVALTSKEE DDSENGVPES TSTDTPPDID LHNQASVPLE PRPLRRESEI; Positive Samples: A-549, Mouse heart, Rat heart; Cellular Location: Lipid-anchor, Membrane, Multi-pass membrane protein
靶标信息
The KIR2 subunit family includes 2. 1, 2. 2, 2. 3 and 2. 4. Unlike G protein-coupled KIR3 subunits, KIR2. 1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity. KIR2. 1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels. In the placenta, KIR2. 1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2. 1 colocalizes with KIR5. 1 in the proximal tubule. KIR2. 1, 2. 2 and 2. 3 associate with the membrane-associated guanylate kinase synapseassociated protein 97 in the cerebellum and heart. Phosphorylation of KIR2. 2 by protein kinase A inhibits the associates with SAP97.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cardiac inward rectifier potassium channel; HHIRK 1; HIRK 1; hIRK1; Inward rectifier K; Inward rectifier K(+) channel Kir2.1; inward rectifier K+ channel KIR2.1; Inward rectifier potassium channel 2; IRK 1; IRK-1; IRK2; LQT 7; Potassium channel, inwardly rectifying subfamily J member 2; potassium channel, inwardly rectifying subfamily J, member 2; potassium inwardly-rectifying channel, subfamily J, member 2; RBL-IRK1; SQT 3
基因别名: ATFB9; HHBIRK1; HHIRK1; IRK1; Kcnf1; KCNJ2; KIR2.1; LQT7; SQT3
UniProt ID: (Human) P63252, (Rat) Q64273, (Mouse) P35561
Entrez Gene ID: (Human) 3759, (Rat) 29712, (Mouse) 16518
inward rectifier potassium channel activity
phosphatidylinositol-4,5-bisphosphate binding
G-protein activated inward rectifier potassium channel activity
identical protein binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
voltage-gated ion channel activity
protein binding
ion channel
transporter
potassium ion transport
potassium ion import
regulation of skeletal muscle contraction via regulation of action potential
magnesium ion transport
cellular potassium ion homeostasis
protein homotetramerization
relaxation of cardiac muscle
regulation of resting membrane potential
regulation of membrane repolarization
cardiac conduction
cellular response to mechanical stimulus
potassium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
regulation of cardiac muscle cell contraction
membrane repolarization during action potential
membrane depolarization during cardiac muscle cell action potential
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
relaxation of skeletal muscle
positive regulation of potassium ion transmembrane transport
cardiac muscle cell action potential
regulation of heart rate
transport
ion transport
regulation of ion transmembrane transport
