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产品信息
PA5-18447
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (KRDDAKYMYYLKK) corresponding to the internal amino acids of KL (aa 424-437).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10983137
产品详细信息
This antibody is predicted to react with mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.
Preliminary analysis showed no signal in Western Blot.
靶标信息
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
beta-glucuronidase activity
signal transducer activity
Ras guanyl-nucleotide exchange factor activity
fibroblast growth factor receptor binding
hormone activity
vitamin D binding
beta-glucosidase activity
1-phosphatidylinositol-3-kinase activity
fibroblast growth factor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
glycosidase
MAPK cascade
carbohydrate metabolic process
energy reserve metabolic process
aging
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of bone mineralization
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
calcium ion homeostasis
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
glycosyl compound metabolic process
