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NeoBiotechnologies
Ksp-Cadherin (Kidney-Specific Cadherin)/CDH16 Recombinant Rabbit Monoclonal Antibody (CDH16/7027R)
产品信息
1014-RBM10-P1
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
CDH16/7027R
抗原
Recombinant human full-length CDH16 protein
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: Normal kidney or renal cell carcinoma. Cellular Localization: Cell surface. Cytoplasm.
Specificity Comments: This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
靶标信息
The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. Cadherin-16, also known as Ksp-Cadherin, is a type I membrane protein which is kidney-specific. Cadherin-16 is expressed exclusively in the basolateral membrane of renal tubular epithelial cells. The human Ksp-cadherin gene (Cadherin-16) maps to chromosome 16q21-proximal 16q22. The mouse Ksp-cadherin gene was localized to a highly syntenic region of distal Chromosome 8.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cadherin; cadherin 16, KSP-cadherin; Cadherin-16; Cadherin-16 (CDH16); CDH 16; Kidney-specific cadherin; KSP-cadherin; Ksp-cadherin antibody
基因别名: CDH16; UNQ695/PRO1340
UniProt ID: (Human) O75309, (Mouse) O88338
Entrez Gene ID: (Human) 1014, (Rat) 307614, (Mouse) 12556
