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L3MBTL1 Antibody (PA5-115488) in IHC (P)
Immunohistochemistry analysis of L3MBTL1 in rat pancreatic tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115488) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-115488
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human L3MBTL1(Accession Q9Y468), corresponding to amino acid residues D452-S502.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900124
产品详细信息
Antibody detects endogenous levels of total L3MBTL1.
靶标信息
L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: H-l(3)mbt; H-l(3)mbt protein; L(3)mbt protein homolog; l(3)mbt-like 1 (Drosophila); L3MBTL1; lethal (3) malignant brain tumor l(3); Lethal(3)malignant brain tumor-like protein 1; RP1-138B7.1
基因别名: C630004G01; dJ138B7.3; H-L(3)MBT; KIAA0681; L3MBT; L3MBTL; L3MBTL1; mKIAA0681; RGD1307316; ZC2HC3
UniProt ID: (Human) Q9Y468, (Mouse) A2A5N8
Entrez Gene ID: (Human) 26013, (Mouse) 241764, (Rat) 311613
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
nucleosome binding
nucleosomal histone binding
SAM domain binding
methylated histone binding
histone binding
identical protein binding
metal ion binding
molecular_function
chromatin/chromatin-binding, or -regulatory protein
transcription, DNA-templated
regulation of mitotic nuclear division
chromatin modification
covalent chromatin modification
hemopoiesis
regulation of megakaryocyte differentiation
negative regulation of transcription, DNA-templated
regulation of cell cycle
regulation of signal transduction by p53 class mediator
regulation of transcription, DNA-templated
regulation of gene expression, epigenetic
biological_process
