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产品信息
H00079603-M05
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2C12
抗原
LASS4 (NP_078828, 57 a.a. approximately 139 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: ERFIGLPLSR WLGVRDQTRR QVKPNATLEK HFLTEGHRPK EPQLSLLAAQ CGLTLQQTQR WFRRRRNQDR PQLTKKFCEA SWR
靶标信息
The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ceramide synthase 4; CerS4; FLJ12089; LAG1 homolog, ceramide synthase 4; LAG1 longevity assurance homolog 4; Sphingosine N-acyltransferase CERS4
基因别名: CERS4; LASS4; Trh1
UniProt ID: (Human) Q9HA82
Entrez Gene ID: (Human) 79603
