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Immunogen sequence: VRAQYVVLLR RSHGDRSRGK RFSQSFREVA GRFLASEAST HLLVFGMEQR LPPNSELVQA VLRLFQEPVP KAALHRHGRL SPRSAQARVT VEWLRVRDDG SNRTSLIDSR LVSVHESGWK AFDVTEAVNF WQQLSRPRQP LLLQVSVQRE HLGPLASGAH KLVRFASQGA PAGLGEPQLE LHTLDLRDYG AQGDCDPEAP MTEGTRCCRQ EMYIDLQGMK WAKNWVLEPP GFLAYECVGT CQQPPEALAF NWPFLGPRQC IASETASLPM IVSIKEGGRT RPQVVSLPNM RVQKCSCASD GALVPRRLQP
Left-right determination factor 1 and 2 (Lefty1/2) belong to the TGF-beta superfamily of proteins and are responsible for determination of left-right positioning of visceral organs during embryogenesis. Lefty1 acts as a regulator of Lefty2 and NODAL as the lack of the former resulted in bilateral expression of nodal, lefty2 and Pitx2 (a homeobox gene normally expressed on the left side and blocks the signal for leftness). Lefty2 may play a role in endometrial bleeding.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: endometrial bleeding associated factor; Endometrial bleeding-associated factor; Left-right determination factor 2; Left-right determination factor A; Left-right determination factor B; left-right determination, factor A; MGC46222; Protein lefty-2; Protein lefty-A; Protein lefty-B; TGF-beta-4; Transforming growth factor beta-4
基因别名: 6030463A22Rik; AV214969; EBAF; LEFTA; Leftb; LEFTY2; LEFTYA; PSEC0024; TGFB4
UniProt ID: (Human) O00292, (Mouse) Q8BMF7
Entrez Gene ID: (Human) 7044, (Mouse) 320202
分子生物学功能: growth factor