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产品信息
PA5-34397
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 16 amino acid synthetic peptide near the center of human LEMD2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551749
产品详细信息
A suggested positive control is 293 cell lysate.
PA5-34397 can be used with blocking peptide PEP-1439.
靶标信息
The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. One such protein, LEMD2 (LEM domain-containing protein 2), is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation. Mutations in LEMD2 are thought be among the possible causes of muscle disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hLEM2; LEM domain-containing protein 2; NET25; nuclear envelope constituent; Nuclear envelope transmembrane protein 25
基因别名: BC026588; CTRCT42; dJ482C21.1; Lem2; LEMD2; NET25
UniProt ID: (Human) Q8NC56, (Mouse) Q6DVA0
Entrez Gene ID: (Human) 221496, (Mouse) 224640
