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产品信息
MA5-48649
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
1D5D10
抗原
Purified recombinant fragment of human CD258 (AA: extra 59-240) expressed in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3093331
靶标信息
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD258; Herpes virus entry mediator ligand; herpesvirus entry mediator ligand; HVEM-L; sCD258; sLIGHT; soluble CD258; soluble LIGHT; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand 1D; Tumor necrosis factor ligand superfamily member 14
基因别名: CD258; HVEM-L; HVEML; LIGHT; LTg; Ly113; TNFSF14; UNQ391/PRO726
UniProt ID: (Human) O43557, (Mouse) Q9QYH9
Entrez Gene ID: (Human) 8740, (Mouse) 50930
immune response
release of cytoplasmic sequestered NF-kappaB
positive regulation of T cell chemotaxis
T cell costimulation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of myoblast differentiation
positive regulation of myoblast fusion
apoptotic process
signal transduction
tumor necrosis factor-mediated signaling pathway
T cell proliferation
T cell activation
T cell homeostasis
cellular response to mechanical stimulus
