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产品信息
PA5-89529
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human LIMS1 (NP_0011804171)
偶联物
形式
Liquid
浓度
0.51 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805631
产品详细信息
Immunogen sequence: MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF YEFEGRKYCE HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC QEVLADIGFV KNAGRHLCRP CHNREKARGL GKYICQKCHA IIDEQPLIFK NDPYHPDHFN CANCGKELTA DARELKGELY CLPCHDKMGV PICGACRRPI EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC ETHYNQLFGD VCFHCNRVIE GDVVSALNKA WCVNCFACST CNTKLTLKNK FVEFDMKPVC KKCYEKFPLE LKKRLKKLAE TLGRK; Positive Samples: Mouse heart; Cellular Location: Cell junction, Cell membrane, Cytoplasmic side, Peripheral membrane protein, focal adhesion
靶标信息
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LIM and senescent cell antigen-like domains 1; LIM and senescent cell antigen-like-containing domain protein 1; LIM-type zinc finger domains 1; Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48; senescent cell antigen
基因别名: 2310016J22Rik; 4921524A02Rik; AI507642; AU021743; AW551584; C430041B13Rik; LIMS1; Lims1l; PINCH; PINCH-1; PINCH1
UniProt ID: (Human) P48059, (Mouse) Q99JW4
Entrez Gene ID: (Human) 3987, (Mouse) 110829
epithelial to mesenchymal transition
cell aging
positive regulation of gene expression
positive regulation of cell-substrate adhesion
cell junction assembly
positive regulation of GTPase activity
establishment of protein localization
negative regulation of transcription, DNA-templated
regulation of epithelial cell proliferation
positive regulation of focal adhesion assembly
cellular response to transforming growth factor beta stimulus
positive regulation of substrate adhesion-dependent cell spreading
cell-matrix adhesion
establishment or maintenance of cell polarity
single organismal cell-cell adhesion
chordate embryonic development
negative regulation of apoptotic process
cell-cell junction organization
negative regulation of epithelial cell proliferation
protein heterooligomerization
negative regulation of neural precursor cell proliferation
negative regulation of hepatocyte proliferation
positive regulation of integrin-mediated signaling pathway
