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Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Monkey, Marmoset, Mouse, Rat, Bovine, Dog, Bat, Elephant, Panda, Horse, Rabbit, Pig (100%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: leucine rich repeat neuronal 6A; leucine-rich repeat; Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine-rich repeat neuronal 6A; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A
基因别名: 4930471K13Rik; AV148400; LERN1; LINGO-1; LINGO1; LRRN6A; UNQ201; UNQ201/PRO227
UniProt ID: (Human) Q96FE5, (Mouse) Q9D1T0
Entrez Gene ID: (Human) 84894, (Rabbit) 100344366, (Pig) 100155465, (Dog) 487660, (Horse) 100061441, (Rat) 315691, (Mouse) 235402