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产品信息
PA5-37375
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length human LIPC
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2554035
产品详细信息
This antibody detects endogenous protein at a molecular weight of 56 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
The Lipase family belongs to one of the most robust genetic superfamilies found in living organisms that includes esterases and thioesterases. Lipase gene products are related by tertiary structure rather than primary amino acid sequence. Balancing the composition and the transport of lipoproteins in human plasma is essential for normal body function and is mediated in part by Hepatic Lipase, also known as HL or LIPC. Rare deficiencies in Hepatic Lipase have been identified in humans which lead to pathologic levels of circulating lipoprotein particles; this condition is associated with coronary artery disease (CAD). Hepatic Lipase is regulated by thyroid hormones and has a dual function as a triglyceride hydrolase and a ligand/bridging factor for receptor-mediated lipoprotein uptake. Hepatic Lipase localizes to the endothelial surfaces of extrahepatic tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hepatic lipase; Hepatic triacylglycerol lipase; HL; Lipase member C; lipase, hepatic; Lysophospholipase; Phospholipase A1; Triacylglycerol lipase
基因别名: HDLCQ12; HL; HTGL; LIPC; LIPH
UniProt ID: (Human) P11150
Entrez Gene ID: (Human) 3990
phospholipase activity
lysophospholipase activity
triglyceride lipase activity
heparin binding
lipid binding
phosphatidylcholine 1-acylhydrolase activity
transferase activity, transferring acyl groups
low-density lipoprotein particle binding
apolipoprotein binding
heparan sulfate proteoglycan binding
acylglycerol lipase activity
lipase
response to hypoxia
liver development
fatty acid biosynthetic process
phosphatidylserine metabolic process
circadian rhythm
cholesterol metabolic process
response to carbohydrate
response to acetate
heparan sulfate proteoglycan biosynthetic process
triglyceride catabolic process
response to nutrient levels
response to magnesium ion
cellular response to hormone stimulus
chylomicron remodeling
very-low-density lipoprotein particle remodeling
intermediate-density lipoprotein particle remodeling
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
chylomicron remnant clearance
low-density lipoprotein particle clearance
phosphatidylcholine catabolic process
response to drug
cholesterol homeostasis
response to amino acid
response to peptide hormone
reverse cholesterol transport
lipid digestion
phosphatidylethanolamine metabolic process
phosphatidic acid metabolic process
glycerophospholipid catabolic process
response to copper ion
developmental growth
protein oligomerization
response to glucocorticoid
response to calcium ion
triglyceride homeostasis
response to fatty acid
