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LMO2 Antibody (PA1-46477) in IHC (P)
Immunohistochemical analysis of LMO2 in formalin fixed and paraffin embedded tissue section of human tonsil. Samples were incubated in LMO2 polyclonal antibody (Product # PA1-46477) using a dilution of 1:500 followed by HRP-labeled secondary antibody and DAB reagent. The sections were further counterstained with hematoxylin. This LMO2 antibody generated an expected nuclear staining in a subset of cells in t... View More
产品信息
PA1-46477
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues 1-100 of an N-terminal portion of human LMO2. [Swiss-Prot# P25791]
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2136561
产品详细信息
The target sequence has 93% sequence homology with zebrafish.
Suggested positive control: Ramos whole cell extracts.
靶标信息
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cysteine-rich protein TTG-2; LIM domain only 2 (rhombotin-like 1); LIM domain only protein 2; LIM only 2; LMO-2; rhombotin 2; Rhombotin-2; rhombotin-like 1; T-cell translocation gene 2; T-cell translocation protein 2
基因别名: LMO2; Rbtn-2; RBTN2; RBTNL1; Rhom-2; RHOM2; TTG2
UniProt ID: (Bovine) Q1LZ94, (Human) P25791, (Mouse) P25801
Entrez Gene ID: (Bovine) 614876, (Human) 4005, (Rat) 362176, (Mouse) 16909
metal ion binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein binding
zinc ion binding
bHLH transcription factor binding
cofactor binding
E-box binding
molecular_function
DNA binding
chromatin binding
