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产品信息
PA5-110651
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2856062
产品详细信息
Immunogen sequence: PAEVLMVEVE NVVHEDFQVT EEVKALTAEI VKTIRDIIAL NPLYRESVLQ MMQAGQRVVD NPIYLSDMGA ALTGAESHEL QDVLEETNIP KRLYKALSLL KKEFELSKLQ QRLGREVEEK IKQTHRKYLL QEQLKIIKKE LGLEKDDKDA
靶标信息
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia. Alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: h LonHS; hLON ATP-dependent protease; Lon protease homolog, mitochondrial; Lon protease-like protein; LONHs; LONP; LONP1; Mitochondrial ATP-dependent protease Lon; mitochondrial lon protease-like protein; Serine protease 15
基因别名: CODASS; hLON; LON; LonHS; LONP; LONP1; PIM1; PRSS15
UniProt ID: (Human) P36776
Entrez Gene ID: (Human) 9361
single-stranded DNA binding
single-stranded RNA binding
ATP-dependent peptidase activity
serine-type endopeptidase activity
protein binding
ATP binding
ADP binding
sequence-specific DNA binding
G-quadruplex DNA binding
DNA polymerase binding
mitochondrial light strand promoter anti-sense binding
mitochondrial heavy strand promoter anti-sense binding
mitochondrial light strand promoter sense binding
mitochondrial heavy strand promoter sense binding
serine protease
mitochondrial genome maintenance
response to hypoxia
misfolded or incompletely synthesized protein catabolic process
mitochondrion organization
aging
response to hormone
response to aluminum ion
mitochondrial DNA metabolic process
cellular response to oxidative stress
chaperone-mediated protein complex assembly
protein homooligomerization
proteolysis involved in cellular protein catabolic process
oxidation-dependent protein catabolic process
regulation of mitochondrial DNA replication
