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Immunogen sequence: RQAPSLPLPG RVGSDTVRGQ ARHPFGFGQV PDNWREVAVG DSTGMARART SVSQQRHGGS ASSVSASAFA STYRQQPSYP QQFPYPQAPF VSQYENYDPA SRTYDQGFVY YRPAGGGVGA GAAAVASAGV IYPYQPRARY EEYGGGEELP EYPPQGFYPA PERPYVPPPP PPPDGLDRRY SHSLYSEGTP GFEQAYPDPG PEAAQAHGGD PRLGWYPPYA NPPPEAYGPP RALEPPYLPV RSSDTPPPGG ERNGAQQGRL SVGSVYRPNQ NGRGLP; Positive Samples: HeLa, A375, A-549, BT-474, HT-1080, Mouse lung, Mouse heart, Rat heart; Cellular Location: extracellular space
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Lysyl oxidase 2; Lysyl oxidase homolog 1; Lysyl oxidase-like protein 1
基因别名: Lox2; Loxl; Loxl1
UniProt ID: (Mouse) P97873
Entrez Gene ID: (Mouse) 16949
分子生物学功能:
oxidase