Invitrogen

LPIN1 Polyclonal Antibody

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LPIN1 Antibody (PA5-30461) in WB

Western Blot using LPIN1 Polyclonal Antibody (Product # PA5-30461). Sample (30 µg of whole cell lysate). Lane A: Jurkat. Lane B: NCI-H929 . 7.5% SDS PAGE. LPIN1 Polyclonal Antibody (Product # PA5-30461) diluted at 1:1,000.

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产品信息

PA5-30461

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 434 and 653 of Human LPIN1

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2547935

产品详细信息

Recommended positive controls: Jurkat, NCI-H929, mouse brown, white adipose.

Predicted reactivity: Mouse (91%), Rat (86%), Pig (90%), Sheep (87%), Bovine (89%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。