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产品信息
PA5-53568
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2643475
产品详细信息
Immunogen sequence: FPVCSPNQAS VLENLRLAVR SQLGFTSVRL PMAGRSSNIW NRIFNFARSR HSGSLALVSA DGDEVVPSQS TSREPERNHT HRSLFSVESD DTDTENERRD MAGASGGVAA PLPQKVPPTT AVEATVGACA SSS
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 89%.
靶标信息
Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP12, also designated ST7, is a member of the LDLR family that is thought to be involved in the internalization of lipophilic molecules and/or signal transduction. LRP12 has been shown to interact with RACK1, MADHIP and Integrin beta-1-binding protein 3. It is widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. Overexpression of LRP12 may be associated with oral tumors, therefore implicating LRP12 as a potential oncogene.
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生物信息学
蛋白别名: LDLR-related protein 12; low density lipoprotein receptor-related protein 12; Low-density lipoprotein receptor-related protein 12; Suppressor of tumorigenicity 7 protein
基因别名: LRP12; ST7
UniProt ID: (Human) Q9Y561
Entrez Gene ID: (Human) 29967
