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Antibody detects endogenous levels of total LTBP1.
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins. The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: LanC (bacterial lantibiotic synthetase component C)-like 1; latent TGF beta binding protein; Latent-transforming growth factor beta-binding protein 1; LTBP-1; MGC163161; TGF-beta-1-BP-1; TGF-beta1-BP-1; Transforming growth factor beta-1-binding protein 1; Transforming growth factor beta-1-masking protein large subunit; transforming growth factor-beta (TGF-beta) masking protein large subunit
基因别名: 9430031G15Rik; 9830146M04; b2b1000Clo; Ltbp-1; LTBP1; Tgfb
UniProt ID: (Human) Q14766, (Mouse) Q8CG19, (Rat) Q00918
Entrez Gene ID: (Human) 4052, (Mouse) 268977, (Rat) 59107