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产品信息
PA5-69243
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the N-terminal region of rat LXR beta
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2690299
产品详细信息
This target displays homology in the following species: Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 93%; Mouse: 100%; Pig: 93%; Rabbit: 100%; Rat: 100%
靶标信息
The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.
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生物信息学
蛋白别名: Liver X receptor beta; nuclear orphan receptor LXR-beta; Nuclear receptor subfamily 1 group H member 2; Orphan nuclear receptor OR-1; Oxysterols receptor LXR-beta; ubiquitous receptor; Ubiquitously-expressed nuclear receptor; UR
基因别名: Lxrb; Nr1h2; OR-1
UniProt ID: (Rat) Q62755
Entrez Gene ID: (Rat) 58851
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
apolipoprotein A-I receptor binding
sequence-specific DNA binding
retinoid X receptor binding
ATPase binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of gene expression
negative regulation of gene expression
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol efflux
positive regulation of lipid storage
negative regulation of cholesterol storage
intracellular receptor signaling pathway
positive regulation of cellular protein metabolic process
negative regulation of lipid transport
positive regulation of cholesterol transport
cholesterol homeostasis
steroid hormone mediated signaling pathway
cellular lipid metabolic process
positive regulation of fatty acid biosynthetic process
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
negative regulation of pinocytosis
positive regulation of lipoprotein lipase activity
lipid homeostasis
positive regulation of high-density lipoprotein particle assembly
positive regulation of pancreatic juice secretion
positive regulation of secretion of lysosomal enzymes
regulation of cholesterol homeostasis
