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Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cancer/testis antigen 116; Ly6/PLAUR domain-containing protein 6B
基因别名: 2310010M24Rik; AW049525; CT116; LYPD6B; LYPD7
UniProt ID: (Human) Q8NI32, (Mouse) Q9D7F2
Entrez Gene ID: (Human) 130576, (Mouse) 71897