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Lactoferrin Antibody (GIC206) in Flow
STAR protocols 2020 -
Figure 6 Induction of Neutrophil Formation from Myeloid Progenitors (A) Representative images of Wright stained cytospins showing the morphology of neutrophils. (B) Flow cytometric analysis of CD11b, CD15, CD16, CD66b, MPO and lactoferrin expression in generated neutrophils.
产品信息
GIC206
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
分类
Monoclonal
类型
Antibody
克隆号
4C5
抗原
Human Lactoferrin
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
纯化类型
purified
保存液
PBS, pH 7.2, with 1% BSA
内含物
0.05% sodium azide
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2536532
产品详细信息
R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients.
靶标信息
Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.
Analyte Specific Reagent
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
生物信息学
蛋白别名: CKRX; epididymis luminal protein 110; Growth-inhibiting protein 12; Kaliocin 1; kaliocin-1; Kaliocin1; lactoferricin; Lactoferricin H; Lactoferrin; lactoferroxin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH; neutrophil lactoferrin; Talalactoferrin
基因别名: GIG12; HEL110; HLF2; LF; LTF
UniProt ID: (Human) E7EQH5
Entrez Gene ID: (Human) 4057
ossification
regulation of cytokine production
retina homeostasis
innate immune response in mucosa
transcription, DNA-templated
proteolysis
ion transport
humoral immune response
antibacterial humoral response
antifungal humoral response
negative regulation of lipopolysaccharide-mediated signaling pathway
regulation of tumor necrosis factor production
negative regulation of ATPase activity
iron assimilation by chelation and transport
positive regulation of osteoblast proliferation
positive regulation of toll-like receptor 4 signaling pathway
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
cellular protein metabolic process
negative regulation by host of viral process
negative regulation of viral genome replication
cell redox homeostasis
positive regulation of osteoblast differentiation
negative regulation of viral process
positive regulation of NF-kappaB transcription factor activity
bone morphogenesis
positive regulation of protein serine/threonine kinase activity
positive regulation of bone mineralization involved in bone maturation
negative regulation of single-species biofilm formation in or on host organism
positive regulation of chondrocyte proliferation
negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
negative regulation of osteoclast development
