NeoBiotechnologies

Lambda Light Chain (B-Cell Marker) Recombinant Rabbit Monoclonal Antibody (LLC/3774R)

Lambda Light Chain (B-Cell Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 3

Lambda Light Chain (B-Cell Marker) Antibody (3535-RBM10-P1) in IHC (P)

Formalin-fixed, paraffin-embedded human spleen stained with Lambda Light Chain Recombinant Rabbit Monoclonal (LLC/3774R). Inset: PBS instead of primary antibody; secondary only negative control.

Lambda Light Chain (B-Cell Marker) Antibody in Immunoelectrophoresis (IE)

Product Image Gallery

产品信息

3535-RBM10-P1

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

免疫电泳 (IE)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

LLC/3774R

抗原

Recombinant full-length human IGL protein

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Antibody is stable for 24 months.

Positive Control: Human tonsil or spleen tissue (IHC). Cellular Localization: Cell Surface, cytoplasmic and secreted

Specificity Comments: This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

靶标信息

Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five types) and two light chains (kappa, lambda; both having a molecular weight of 22.5 kDa). Kappa and lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of kappa to lambda is 70:30. Antibodies to the kappa light chain are reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

仅用于科研。不用于诊断过程。未经明确授权不得转售。