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产品信息
PA5-19990
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to amino acids 264 to 280 of the short form and 281 to 298 of the long form of human Livin
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11156011
产品详细信息
In Western blot applications, this antibody detects a band at ~33kDa. A suggested positive control is Raji cell lysate.
PA5-19990 can be used with blocking peptide PEP-0114.
靶标信息
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. Recently, it has been identified that a novel human inhibitor of apoptosis protein (IAP) family member termed Livin or ML-IAP, which contains a single baculoviral IAP repeat (BIR) domain and a COOH-terminal RING finger domain. Livin gene has two splicing variants that contain open reading frames of 298 and 280 amino acids and both contained a single copy of baculovirus IAP repeat (BIR) and RING domain. Both of the isoforms inhibit TNFa induced apoptosis in Jurkat cells. Livin expression is low in adult tissues. It is relatively expressed at a higher level in developmental tissues and in many cancer cells.
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生物信息学
蛋白别名: Baculoviral IAP repeat-containing protein 7; KIAP; Kidney inhibitor of apoptosis protein; Livin; livin inhibitor of apoptosis; Melanoma inhibitor of apoptosis protein; ML-IAP; RING finger protein 50; RING-type E3 ubiquitin transferase BIRC7; RP11-261N11.7
基因别名: BIRC7; KIAP; LIVIN; ML-IAP; MLIAP; RNF50; UNQ5800/PRO19607/PRO21344
UniProt ID: (Human) Q96CA5
Entrez Gene ID: (Human) 79444
apoptotic process
activation of JUN kinase activity
regulation of signal transduction
protein ubiquitination
regulation of cell proliferation
negative regulation of apoptotic process
regulation of natural killer cell apoptotic process
mitotic spindle assembly
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
