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Livin Antibody (PA5-75440) in WB
Western blot analysis of Livin in Lane 1: A549 whole cell lysate (40 µg), Lane 2: HEK293T whole cell lysate (40 µg), Lane 3: the lung tissue lysate of mouse (40 µg), Lane 4: PC12 whole cell lysate (40 µg). Samples were incubated with Livin polyclonal antibody (Product # PA5-75440) at a dilution of 1:500.
产品信息
PA5-75440
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 180-230 of Human Livin.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2719168
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. Recently, it has been identified that a novel human inhibitor of apoptosis protein (IAP) family member termed Livin or ML-IAP, which contains a single baculoviral IAP repeat (BIR) domain and a COOH-terminal RING finger domain. Livin gene has two splicing variants that contain open reading frames of 298 and 280 amino acids and both contained a single copy of baculovirus IAP repeat (BIR) and RING domain. Both of the isoforms inhibit TNFa induced apoptosis in Jurkat cells. Livin expression is low in adult tissues. It is relatively expressed at a higher level in developmental tissues and in many cancer cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Baculoviral IAP repeat-containing protein 7; KIAP; Kidney inhibitor of apoptosis protein; Livin; livin inhibitor of apoptosis; Melanoma inhibitor of apoptosis protein; ML-IAP; RING finger protein 50; RING-type E3 ubiquitin transferase BIRC7; RP11-261N11.7
基因别名: BIRC7; E130019N06; KIAP; LIVIN; ML-IAP; MLIAP; RNF50; UNQ5800/PRO19607/PRO21344
UniProt ID: (Human) Q96CA5, (Mouse) A2AWP0
Entrez Gene ID: (Human) 79444, (Mouse) 329581
ubiquitin-protein transferase activity
cysteine-type endopeptidase inhibitor activity
protein binding
zinc ion binding
ligase activity
enzyme binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
peptidase inhibitor activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
protease inhibitor
apoptotic process
activation of JUN kinase activity
regulation of signal transduction
protein ubiquitination
regulation of cell proliferation
negative regulation of apoptotic process
regulation of natural killer cell apoptotic process
mitotic spindle assembly
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of peptidase activity
