Invitrogen

CD8 beta Monoclonal Antibody (CT-CD8b), FITC

CD8 beta Antibody in Flow Cytometry (Flow)

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CD8 beta Antibody (MA5-17847) in Flow

Flow cytometric analysis of Thymus cells stained using anti-CD8b/LYT3 Monoclonal Antibody (Product # MA5-17847) at a 0.1 µg/10^6 cells dilution.

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产品信息

MA5-17847

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

0.1 µg/1x10^6 cells

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其他PubMed (Misc)

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产品规格

种属反应

Mouse

已发表种属

Mouse

宿主/亚型

Rat / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

CT-CD8b

抗原

Mouse CD8 β

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Protein G

保存液

PBS with 4-5mg/mL BSA

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2539231

靶标信息

The CD8B antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

Inactivation of tumor-specific CD8⁺ CTLs by tumor-infiltrating tolerogenic dendritic cells.

Immunology and cell biology

Harimoto H,Shimizu M,Nakagawa Y,Nakatsuka K,Wakabayashi A,Sakamoto C,Takahashi H

MA5-17847 was used in flow cytometry to elucidate the role of dendritic cells in cancer immunosurveillance failure

Tue Oct 01 00:00:00 EDT 2013

Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells.

Brain, behavior, and immunity

Mandal M,Marzouk AC,Donnelly R,Ponzio NM

MA5-17847 was used in flow cytometry to examine how maternal immune stimulation affects the adaptive immune system and pathobiology of the offspring

Fri Jul 01 00:00:00 EDT 2011

Lymphoid precursors in intestinal cryptopatches express CCR6 and undergo dysregulated development in the absence of CCR6.

Journal of immunology (Baltimore, Md. : 1950)

Lügering A,Kucharzik T,Soler D,Picarella D,Hudson JT,Williams IR

MA5-17847 was used in flow cytometry to study CCR6 expression by T lymphocyte precursors undergoing extrathymic differentiation in intestinal cryptopatches.

Mon Sep 01 00:00:00 EDT 2003

Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity.

Journal of immunology (Baltimore, Md. : 1950)

Cawthon AG,Alexander-Miller MA

MA5-17847 was used in flow cytometry to investigate the control of functional avidity in response to viral infection.

Tue Oct 01 00:00:00 EDT 2002

Cellular and molecular characterization of the scurfy mouse mutant.

Journal of immunology (Baltimore, Md. : 1950)

Clark LB,Appleby MW,Brunkow ME,Wilkinson JE,Ziegler SF,Ramsdell F

MA5-17847 was used in flow cytometry to further characterize mice hemizygous for scurfy.

Mon Mar 01 00:00:00 EST 1999

生物信息学

蛋白别名: CD8; CD8alpha; CD8b; CD8beta; Leu-2; Lymphocyte antigen 3; MAL; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-3

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基因别名: Cd8b; Cd8b1; Ly-3; Ly-C; Lyt-3; Lyt3

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UniProt ID: (Mouse) P10300

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Entrez Gene ID: (Mouse) 12526

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功能

protein binding defense/immunity protein immunoglobulin receptor superfamily

参与通路

immune system process