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产品信息
MA5-17914
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OX-86
抗原
Recombinant mouse OX-40 antigen
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Protein G
保存液
PBS with 4-5mg/mL BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2539298
靶标信息
OX40 is a protein receptor found on the surface of T cells, a type of white blood cell that plays a crucial role in the immune system. When activated, OX40 promotes the proliferation and survival of T cells, leading to a stronger immune response against cancer cells and infectious agents. OX40 agonists, which are drugs that activate OX40, have shown promising results in preclinical and clinical studies as a potential immunotherapy for cancer. They can enhance the efficacy of other cancer treatments such as chemotherapy and checkpoint inhibitors, and may also have applications in autoimmune diseases and allergies.
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生物信息学
蛋白别名: CD134; OX40 antigen; OX40L receptor; tax-transcriptionally activated glycoprotein 1; Tumor necrosis factor receptor superfamily member 4
基因别名: ACT35; CD134; Ly-70; Ox40; Tnfrsf4; Txgp1; TXGP1L
UniProt ID: (Mouse) P47741
Entrez Gene ID: (Mouse) 22163
inflammatory response
cellular defense response
programmed cell death
positive regulation of B cell proliferation
tumor necrosis factor-mediated signaling pathway
T cell proliferation
regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of protein kinase activity
negative regulation of transcription, DNA-templated
negative regulation of cytokine secretion
positive regulation of immunoglobulin secretion
negative regulation of activation-induced cell death of T cells
negative regulation of extrinsic apoptotic signaling pathway
