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FGF13 Antibody (MA5-45654) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with FGFA/FHFA (pan) monoclonal antibody (Product # MA5-45654) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1,000; 1:5,000 for 60 min RT, 5 min RT. Localization: Cell Projection, Nucleus, Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) ... View More
产品信息
MA5-45654
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
N235/22
抗原
Synthetic peptide amino acids 2-18 (AAAIASSLIRQKRQARE) of human FHF2A.
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
47.35mM phosphate/2.15mM MES, pH 7.4, with 2mM EDTA, 0.17066µM Pentachlorophenol, 0.8mM ethanol
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2932108
产品详细信息
100% identical to rat, 94% identical to mouse. >80% identity with FGF12A/FHF1A, FGF14A/FHF4A and FGF11A/FHF3A.
1 µg/mL of MA5-45654 was sufficient for detection of FGFA/FHFA (pan) in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 30kDa. Does not cross-react with FGF13B/FHF2B. Cross reacts with FGF12A/FHF1A and FGF14A/FHF4A.
This antibody was formerly sold as clone S235-22.
靶标信息
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AFGF; ECGFA; ECGFB; FGF; FGF 1; FGF alpha; FGF-13; FGF13A; FGFA; FHF-2; Fibroblast growth factor; Fibroblast growth factor 13; Fibroblast growth factor homologous factor 2; GLIO703; HBGF 1; HBGF1
基因别名: FGF-13; FGF13; FGF2; FHF-2; FHF2
UniProt ID: (Human) Q92913, (Rat) Q9ERW3, (Mouse) P70377
Entrez Gene ID: (Human) 2258, (Rat) 84488, (Mouse) 14168
MAPK cascade
neuron migration
negative regulation of microtubule depolymerization
signal transduction
cell-cell signaling
nervous system development
learning
memory
hippocampus development
cerebral cortex cell migration
activation of protein kinase activity
establishment of neuroblast polarity
microtubule polymerization
negative regulation of collateral sprouting
protein localization to plasma membrane
apoptotic process
cell proliferation
positive regulation of protein kinase activity
