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Parvalbumin Antibody (MA5-45928) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using undifferentiated SH-SY5Y cells. Samples were incubated with Parvalbumin monoclonal antibody (Product # MA5-45928) at 1:250, followed by AlexaFluor 488. Counterstain used was phalloidin (Alexa 647, red), beta tubulin (Anti-beta III Tubulin Ab, Alexa 555, magenta) Hoechst (blue). (A) Phalloidin (B) Anti-beta III Tubulin Ab. (C) Parvalbumin antibody. (D) Ho... View More
产品信息
MA5-45928
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
C12
抗原
Synthetic peptide from the full length Rat Parvalbumin protein
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
9.09mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine
内含物
no preservative
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2932382
产品详细信息
A 1:500 dilution of MA5-45928 was sufficient for detection of Parvalbumin in 15 µg of Rat Brain by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Detects 12 kDa.
靶标信息
Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HGNC:9704; MGC116759; Parvalbumin (calcium binding protein); Parvalbumin alpha
基因别名: D22S749; PALB1; Parv; PV; Pva; PVALB
UniProt ID: (Human) P20472, (Rat) P02625, (Mouse) P32848
Entrez Gene ID: (Human) 5816, (Rat) 25269, (Mouse) 19293
