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MAFK Antibody (PA5-115534) in ICC/IF
Immunocytochemistry analysis of MAFK in A549 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115534). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
产品信息
PA5-115534
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MAFK(Accession O60675), corresponding to amino acid residues M1-K46.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900170
产品详细信息
Antibody detects endogenous levels of total MAFK.
靶标信息
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: basic-leucine zipper transcription factor MafK; Erythroid transcription factor NF-E2 p18 subunit; FLJ32205; MGC71717; nuclear factor erythroid-2, ubiquitous (p18); nuclear factor, erythroid derived 2, ubiquitous; p18 NF-E2; Transcription factor MafK; v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein K; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K; v-maf musculoaponeurotic fibrosarcoma oncogene homolog K
基因别名: AW061068; MAFK; NF-E2; NFE2U; P18
UniProt ID: (Human) O60675, (Mouse) Q61827
Entrez Gene ID: (Human) 7975, (Rat) 246760, (Mouse) 17135
transcription regulatory region sequence-specific DNA binding
transcription cofactor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
RING-like zinc finger domain binding
DNA binding
protein binding
sequence-specific DNA binding
basic leucine zipper transcription factor
