Invitrogen

MAG Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

查看其他11个MAG抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (4)
高级验证 (1)

MAG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MAG Antibody (PA5-79620) in IHC (P)

Immunohistochemical analysis of MAG in a paraffin-embedded section of rat cerebellum tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution).The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2 μg/mL rabbit anti-MAG antibody (Product # PA5-79620) overnight at 4°C. Peroxidase Conjugated Goat Anti-rabbit IgG was used... View More

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MAG Antibody — Antibody specificity was demonstrated by detection of differential basal expression of the target across tissues tested owing to their inherent genetic constitution. Relative expression of Myelin-associated glycoprotein was observed in mouse and rat brain and cerebellum when compared to other tissues like mouse stomach, large intestine and skeletal muscle using Anti-MAG Polyclonal Antibody (Product # PA5-79620) in Western Blot. {RE}

产品信息

PA5-79620

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL

免疫组化（石蜡） (IHC (P))

2-5 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence at the N-terminus of human MAG (114-132aa KYYFRGDLGGYNQYTFSEH).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5mg BSA

内含物

0.05mg sodium azide, 0.05mg thimerosal

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2746735

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

靶标信息

The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 1B236; Brain neuron cytoplasmic protein 3; Myelin-associated glycoprotein; S-MAG (C-term.); sialic acid binding Ig-like lectin 4A; Sialic acid-binding Ig-like lectin 4a; sialic acid-binding immunoglobulin-like lectin 4A; Siglec-4a

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基因别名: GMA; MAG; S-MAG; SIGLEC-4A; SIGLEC4A; SPG75

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UniProt ID: (Human) P20916, (Rat) P07722, (Mouse) P20917

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Entrez Gene ID: (Human) 4099, (Rat) 29409, (Mouse) 17136

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功能

receptor binding protein kinase binding carbohydrate binding protein binding immunoglobulin superfamily cell adhesion molecule

参与通路

cell adhesion positive regulation of myelination positive regulation of astrocyte differentiation negative regulation of axonogenesis leukocyte migration cellular response to mechanical stimulus nervous system development negative regulation of neuron projection development substantia nigra development negative regulation of neuron differentiation