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A suggested positive control is EL4 cell lysate.
PA5-19995 can be used with blocking peptide PEP-0117.
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MAP-1; MAP1; Modulator of apoptosis 1; paraneoplastic antigen like 4; Paraneoplastic antigen Ma4; paraneoplastic Ma antigen family member 4
基因别名: AA987038; MAP-1; MOAP1; PNMA4
UniProt ID: (Human) Q96BY2, (Mouse) Q9ERH6
Entrez Gene ID: (Human) 64112, (Mouse) 64113